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Complement Regulatory Proteins

Autor: B. Paul Morgan, Claire L. Harris

Limbă:

Legare: Copertă tare

Editura: Elsevier Science Publishing Co Inc

Disponibilitate: La editor doar la comandă

Expediem în 28-34 zile

794.57 lei

From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in t...

Informații despre carte

Autor

B. Paul Morgan, Claire L. Harris

Limbă

engleză

Legare

Carte - Copertă tare

Publicat

1999

Pagini

382

EAN

9780125069656

ISBN

0125069650

Enbook ID

04495185

Editura

Elsevier Science Publishing Co Inc

Greutate

790

Dimensiuni

152 x 229 x 23

Descriere completă

From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the 'nuts-and-bolts' of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious. Key features include: Complement regulators - structure, functional roles and mode of action; Comprehensive reviews of each of the individual regulators; Roles of Complement regulators in vivo, in health and disease; Consequences of deficiency; Roles in the reproductive system; Interactions with pathogens; Exploitation for therapy; and, Complement regulators in other species.

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