Anaphase promoting complex: structure and expression

Name: Anaphase promoting complex: structure and expression
Brand: LAP Lambert Academic Publishing
SKU: 9783659875595
Price: 294.33 RON
Availability: InStock

Autor: Hamzeh Rahimi

Limbă:

Legare: Carte broșată

Editura: LAP Lambert Academic Publishing

Disponibilitate: În depozitul extern

Expediem în 5-8 zile

294.33 lei

The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role...

Informații despre carte

Autor

Hamzeh Rahimi

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2016

Pagini

184

EAN

9783659875595

Enbook ID

14441403

Editura

LAP Lambert Academic Publishing

Greutate

290

Dimensiuni

150 x 220 x 11

Descriere completă

The anaphase promoting complex (APC) is the largest Cullin-RING E3 ligase that plays a critical role in cell cycle control and known as target of anti-cancer agents. APC regulates the onset of chromosome separation and mitotic exit via securin and cyclin B degradation, respectively. APC controls this process by mediating ubiquitin conjugation to substrates such as cyclin B and securin. The objective of this study was to evaluate the expression pattern of APC subunits in cancer cell lines and AML patients. Moreover, inhibitory compounds were designed based on the 3D structure of the APC and their inhibitory effects were investigated on HeLa and MDA-MB-435 cell lines. To do this, the 3D structure of APC was predicted using homology modelling and molecular dynamic simulation. Interaction among APC subunits were studied by using protein-protein docking methods. It was found that catalytic subunits of APC over-expressed in cancer cell lines and AML patients. Furthermore, the APC subunits assembly and activation was demonstrated at the atomic-level.

S-ar putea să te intereseze

Clienții care au cumpărat această carte au mai cumpărat și

Cele mai căutate

Categories

Authors

Publishers

Produse

Produse

Cele mai căutate

Categories

Authors

Publishers

Produse

Produse

Anaphase promoting complex: structure and expression

Informații despre carte

Descriere completă

S-ar putea să te intereseze

Clienții care au cumpărat această carte au mai cumpărat și