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Carte Analyzing T Cell Responses D. Nagorsen

Analyzing T Cell Responses

How to analyze cellular immune responses against tumor associates antigens

Autor: D. Nagorsen, F. Marincola
Limbă: engleză
Legare: Copertă tare
Editura: Springer-Verlag New York Inc.
Disponibilitate: În depozitul extern în cantități mici
Expediem în 11-15 zile
893.22 lei
This book reviews, describes, categorizes and provides a critical assessment of all assays that have...

Informații despre carte

Autor
D. Nagorsen, F. Marincola
Limbă
engleză
Legare
Carte - Copertă tare
Publicat
2005
Pagini
314
EAN
9781402036224
ISBN
1402036221
Enbook ID
01416238
Editura
Springer-Verlag New York Inc.
Greutate
800
Dimensiuni
156 x 232 x 25

Descriere completă

This book reviews, describes, categorizes and provides a critical assessment of all assays that have been used for the monitoring of antigen-specific immune responses. In particular, it emphasizes a global approach to the analysis of T cell mediated target/host interactions at the systemic and the peripheral level when such interactions are supposed to occur. In addition, the tools described here could be utilized for the search of surrogate biomarkers predictive of treatment responsiveness and/or clinical outcome that are of interest to the biotechnology industry. In detail, this book provides an overview of antigen-specific immune biology in human models of tumor and viral disease, discusses modulation of such responses through immune escape and presents cellular assays (cytoxicity, proliferation, cytokine production using ELISPOT, intracellular staining or cytometric assessment, detection of antigen-specific T cells with tetrameric HLA/epitope complexes or MHC-IG dimers, T cell receptor analysis, assessment of T cell receptor/HLA interactions using peptide/HLA-Green Fluorescent Protein complexes incorporation) and molecular assays including quantitative real-time PCR and gene profiling for evaluation of systemic and peripheral immune responses.

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