Analytical method development

Name: Analytical method development
Brand: LAP Lambert Academic Publishing
SKU: 9783846528662
Price: 236.07 RON
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Analytical and Bioanalytical Method Development of Amlodipine Besylate and Enalapril Maleate and its Formulation

Autor: Pournima Patil, Harinath More, Sachin Pishwikar

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Editura: LAP Lambert Academic Publishing

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Combination of drugs is often formulated to increase the potency of the dosage form and to decrease...

Informații despre carte

Autor

Pournima Patil, Harinath More, Sachin Pishwikar

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2011

Pagini

EAN

9783846528662

Enbook ID

07045588

Editura

LAP Lambert Academic Publishing

Greutate

159

Dimensiuni

150 x 220 x 6

Descriere completă

Combination of drugs is often formulated to increase the potency of the dosage form and to decrease the number of tablets taken for the management of diseases. In present work, methods of simultaneous estimation of Olmesartan Medoxomil and Amlodipine besylate in their combined dosage form are developed, as literature survey revealed that no method for simultaneous estimation of these drugs is reported. After studying the stability of both the drugs in methanol and acetonitrile, Olmesartan shows poor stability in methanol whereas in acetonitrile it shows good stability therefore acetonitrile is used for method development. Bioanalytical method validation was done by USFDA guidelines. Bioanalytical method validation was done by USFDA guidelines. Recoveries in all these method were in the range of 98-101%. Results obtained were statistically validated and were found to be reproducible. These methods can be applied for routine analysis of formulations containing these drugs. For analytical methods validation parameters such as linearity, precision, accuracy, specificity, limit of detection, limit of quantitation and robustness were determined according to ICH Q2B guidelines.

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Analytical method development

Analytical and Bioanalytical Method Development of Amlodipine Besylate and Enalapril Maleate and its Formulation

Informații despre carte

Descriere completă

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