Airways Smooth Muscle

Name: Airways Smooth Muscle
Brand: Springer Basel
SKU: 9783034875608
Price: 552.06 RON
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Structure, Innervation and Neurotransmission

Autor: David Raeburn, Mark A. Giembycz

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Editura: Springer Basel

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Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely t...

Informații despre carte

Autor

David Raeburn, Mark A. Giembycz

Limbă

engleză

Legare

Carte - Carte broșată

Publicat

2012

Pagini

332

EAN

9783034875608

ISBN

3034875606

Enbook ID

02644623

Editura

Springer Basel

Greutate

588

Dimensiuni

170 x 244 x 19

Descriere completă

Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter.

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Airways Smooth Muscle

Structure, Innervation and Neurotransmission

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