Inhibitors of Protein-Protein Interactions: Small Molecules, Peptides and Macrocycles

Many biological functions involve the formation of protein-protein complexes and the inhibition of this process has led to significant interest in pharmaceutical research and the development of novel therapies for numerous diseases. This book comprehensively covers the various approaches to the inhibition of protein-protein interactions from small molecule inhibitors to peptidomimetics, cyclic peptides, macrocycles and antibodies. Illustrated throughout with successful case studies this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.