Iron Physiology and Pathophysiology in Humans

PART I - CELLULAR IRON METABOLISM (1) Proteins of Iron Homeostasis - Surjit Kaila Srai and Paul Sharp (2) Cellular Iron Physiology - Martina U. Muckenthaler and Roland Lill (3) Regulation of Cellular Iron Metabolism in Mammalian Cells - Tracey A. Rouault (4) Concentrating, Storing and Detoxifying Iron: The Ferritins and Hemosiderin - Elizabeth C. Theil PART II - IRON PHYSIOLOGY (5) Iron Nutrition - Weng-In Leong and Bo Lonnerdal (6) Intestinal Iron Absorption - Andrew T McKie and Robert J Simpson (7) Plasma Iron and Iron Delivery to the Tissues - Ross M. Graham, Anita C.G. Chua and Debbie Trinder (8) Iron Salvage Pathways - Ann Smith (9) Molecular Regulation of Systemic Iron Metabolism - Tomas Ganz and Sophie Vaulont (10) Erythroid Iron Metabolism - Prem Ponka and Alex D. Sheftel (11) Iron and the Reticuloendothelial System - Guenter Weiss (12) Iron and the Immune System - Hal Drakesmith, Graca Porto and Maria de Sousa PART III - DISORDERS OF IRON HOMEOSTASIS -Anemias (13) Iron Deficiency - Barry Skikne and Chaim Hershko (14) The Liabilities of Iron Deficiency - John L. Beard and Carrie Durwood (15) The Anemia of Inflammation and Chronic Disease - Cindy N. Roy (16) Disorders of Red Cell Production and the Iron-Loading Anemias - Stefano Rivella PART IV - DISORDERS OF IRON HOMEOSTASIS - IRON OVERLOAD AND RELATED CONDITIONS (17) The Pathology of Hepatic Iron Overload -Yves Deungier and Bruno Turlin (18) Hepatic Pathobiology of Iron Overload - Richard G. Ruddell and Grant A Ramm (19) HFE-Associated Hereditary Hemochromatosis - Richard Skoien and Lawrie W. Powell (20) Non-HFE Hemochromatosis - Daniel F. Wallace and V. Nathan Subramaniam (21) Miscellaneous Iron-Related Disorders - Carole Beaumont (22) Iron and Liver Disease - Darrell H.G. Crawford, Linda M. Fletcher and Kris V. Kowdley (23) Neuropathology and Iron: Central Nervous System Iron Homeostasis - Sarah J. Texel, Xueying Xu, Sokhon Pin and Z. Leah Harris (24) Iron Metabolism in Cancer and Infection - Sergei Nekhai and Victor R. Gorduek PART V - CLINICAL DIAGNOSIS AND THERAPY (25) Estimation of Body Iron Stores - Mark Worwood (26) Genetic Testing for Disorders of Iron Homeostasis - James C. Barton, Pauline L. Lee and Corwin Q. Edwards (27) The Properties of Therapeutically Useful Iron Chelators - Robert C. Hider and Yong Min Ma (28) Clinical Use of Iron Chelators - John B. Porter and Chaim Hershko, PART VI- MODEL SYSTEMS FOR STUDYING IRON HOMEOSTASIS (29) Mammalian Models of Iron Homeostasis - Robert S. Britton, Bruce R. Bacon and Robert E. Fleming (30) Yeast Iron Metabolism - Caroline C. Philpott (31) Zebrafish Models of Heme Synthesis and Iron Metabolism- Paula Goodman Fraenkel